Association of interleukin-6 174 G>C (rs1800795) gene polymorphisms in a patient with arteriosclerosis in Najaf
Atherosclerosis is a common chronic disease that mainly affects medium-sized arteries. Clinically, it may present manifest as peripheral arterial disease, ischemic heart disease, or cerebrovascular disease. The aim of this study was to investigate the association of IL-6 gene polymorphism (rs1800795) with Arteriosclerosis in the AL-Najaf population. Blood samples were taken from 40 arteriosclerosis patients and 20 as a control. Tetra amplification thermal mutagenesis system (T-ARMS-PCR) technique was used to detect the Interleukin-6 (IL-6-174 G/C) (rs1800795) gene polymorphism. The results of the genotype apportionment of the IL-6 gene revealed a significant increase (p =0.016) increase in the GG genotype and the G allele in the -174 G/C single nucleotide polymorphism (SPN) in atherosclerotic patients compared to controls, and the results were significantly more significant. You are more likely to be a mutant allele than controls (OR = 2.231 CI = 1.160–4.291, p = 0.01). These results indicate an association of polymorphisms of IL-6 -174G/C in a patient with atherosclerosis from Iraq.
Atherosclerosis, Interleukin 6, IL-6 gene polymorphism, Tetra ARMS – PCR.