The relationship of Chemerin with type I and II diabetes patients in Kirkuk city

Abstract

Background: Hyperglycemia, which can be caused by problems with insulin action, insulin secretion, or both, is one of the most prevalent symptoms of diabetes, which is one of the most common endocrine illnesses. Diabetes is the root cause of hyperglycemia, which in turn causes the body's metabolism to become dysfunctional. Aims:  The study aimed at determining the levels of Chemerin in the serum of patients with type 1 and type 2 diabetes. Materials and methods: The study was conducted in Kirkuk City from the period between December 1st 2021 until the end of April 2022 and involved 100 diabetic patients (50 of the first type and 50 of the second type). The first group were children under 15 years while the second group aged between 45-64 years, blood was extracted from those patients who attended Kirkuk General Hospital. The control group involved 50 healthy individuals of matched age for type one and type 2 diabetes and apparently were healthy without history of diabetes or any chronic diseases.  (25 children under the age of 15 as a control group (1) for patients with type 1 diabetes and 25 adults for type 2 diabetes). Five ml of venous blood was collected to assess blood sugar and chemerin levels. Results: The results showed that the elevated level of chemerin (13.66±1.73) ng/ml was in patients with type 2 diabetes, compared to control group 5.28±1.83 ng/ml. The study also revealed that chemerin level was higher (16.19±0.72) ng/ml in patients with type 2 diabetes compared to control group 5.99±1.66 ng/ml. In addition, it illustrated that the chemerin level (16.19±0.72) ng/ml was highest in patients with type 2 diabetes compared to type 1 diabetes 13.66±1.73 ng/ml. The difference between the two groups was statistically significant (P=0.001). Regarding blood sugar, high rate of blood sugar was recorded in people with type 1 diabetes 319.3±25.7 followed by type 2 diabetes 262.2±84.01.Normal blood sugar was recorded in the control group 88.16±10.52. Conclusion: Chemerin level was higher in diabetic patients especially in patients with retinopathy.  We recommend that chemerin levels can be used to assess the condition of patients with diabetes mellitus.