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Lujain Adnan Khanger Hutheyfa Abdulhussein Ali Murtaza Hamza Muhammad

Abstract

Cancer immunotherapy (CI) refers to methods that enable the use of the immune system and its components as cancer treatment. As a result of its capacity to inhibit cell proliferation, IL-24 has drawn a lot of interest. Additionally, by activating autophagy and death in cancer cells, IL-24 functions as a self-sufficient anti-cancer agent. A number of human cancers can become cytotoxic when exposed to IL-24. In the current investigation, ductal mammary gland carcinoma treated with various dosages of IL-24 (10, 50, and 100 pg/ml). The optimum cytotoxic concentration of IL-24 on ductal mammary gland carcinoma was determined using the MTT test. Using the AO/EB (Acridine-Orange and Ethedium Bromide) Technique It also enables the differentiation of healthy cells, necrotic cells, and cells that have undergone early and late apoptosis. LC-3, caspase 8, and caspase 9 levels of specific apoptosis and autophagy were measured utilizing a gene expression technique.

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Keywords

: health; patience; Anti-Tumor Factor

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