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Qabas Abdulridha Abbas Hasnawi Rand Muhammed Abdul-Hussein Al-Husseini

Abstract

Asthma is a chronic respiratory disorder characterized by a heterogeneous and multifactorial background. Asthma is a complex genetic disorder with a strong environmental impact, and symptoms clinically associated with asthma include wheezing, coughing, chest tightness and shortness of breath. Amplification refractory mutation system-polymerase chain reaction (ARMS-PCR) was used for the detection of Interleukin-13 (IL-13) gene polymorphism -1112 C>T (rs1800925). The genotype distribution results of the IL-13 gene showed a significant increase (p<0.05) in the CT genotype and T allele of the -1112 C>T single nucleotide polymorphism (SPN) in asthma patients than in controls, and they were significantly more likely to have the mutant allele than controls (OR=34.211 95%CI= 4. 576 -255.771, p=0.01). The results showed that the levels of the IL-13 recorded a significant increase (P<0.05) in patients. The study showed that the IL-13 heterozygote genotype (CT) and the homozygote TT significantly had higher IL-13 levels compared to the IL-13 CC genotype in patients and controls.These results imply an association between the polymorphism of the IL-13 -1112 C>T and IL-13 cytokine levels in the Iraqi asthma patient.

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Keywords

Asthma, Interleukin-13, IL-13gene polymorphism, ARMS –PCR.

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