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Nawras Ali Hussein Al-Jubouri Dalal Abdul Hussein Kazem Al-Issawi

Abstract

The study was performed at the animal house of Biology department , College of Education for girls and included the use of 75 laboratory rat animals of Sprague-Dawley strain , randomly divided into five equal groups: the first group was administrated with distilled water (negative control) ,the second group was orally administrated with Carbamazepine drug 200mg/kg/day, the third group was orally administrated with aqueous extract of Broccoli (Brassica oleracea L. var . Italica ) 1500 mg /kg/ day + Carbamazepine drug ,the fourth group was orally administrated with aqueous extract of Broccoli (Brassica oleracea L. var . Italica ) 2500 mg /kg/ day + Carbamazepine drug, the fifth group was orally administrated with aqueous extract of Broccoli (Brassica oleracea L. var . Italica ) 3500 mg /kg/ day + Carbamazepine drug. The treatment of all groups (experimental animals ) was once daily (1- 7, 1-16, 1-20 day of pregnancy) . The results of the statistical analysis of the current study showed that there was a significant increase (P < 0.05) in the levels of malondialdehyde (MDA) in the serum of pregnant mothers treated with carbamazepine 200 mg / kg when compared with the control group during the three stages of pregnancy (7,16,20), while the results of the statistical analysis showed that there were no significant differences (P < 0.05) in the levels of malondialdehyde (MDA) in the serum of pregnant mothers in the treated groups (aqueous extract of broccoli 1500 mg/kg ₊ drug carbamazepine 200 mg/kg, aqueous extract of broccoli 2500 mg/kg ₊ carbamazepine 200 mg/kg, aqueous extract of broccoli 3500 mg/kg ₊ carbamazepine 200 mg/kg) in comparison with the control group during the three stages of pregnancy (7,16,20). We conclude from the current study that broccoli has a role in preventing the side effects of carbamazepine drug, so the pregnant mother should eat broccoli during pregnancy.

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Keywords

Malondialdehyde; serum of pregnant mothers; Carbamazepine

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