A Correlation assay of Serotonin levels and Leukemia types

Abstract

Objective:  Serotonin, also known as 5-hydroxytryptamine (5-HT), is a monoamine neurotransmitter present in numerous tissues. The majority of the body's serotonin, roughly 95%, is produced in the digestive tract, specifically in enterochromaffin (EC) cells. Leukemia is a type of cancer that affects the blood and bone marrow, and it is classified as a hematopoietic tissue tumor. The four primary forms of leukemia include acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML), chronic lymphocytic leukemia (CLL), and chronic myeloid leukemia (CML). Aim of the study: The study aimed to determine the serotonin levels in patients with types of leukemia. Methods: This study was composed of 40 patients diagnosed with ALL, AML, CLL, and CML. The blood samples were collected to measure the serotonin levels by ELISA technique. Results: The correlation between the four types of leukemia and serotonin included in fourteen patients diagnosed with ALL showed (mean: 1.78 ng/ml, SD:0.09) while AML included nine patients showed (mean: 1.73 ng/ml, SD:0.02), CLL included seven patients showed (mean: 1.72 ng/ml, SD:0.02) finally the serotonin level in CML included ten patients showed (mean: 1.72 ng/ml, SD:0.03), there is an increasingly significant association between type of leukemia and serotonin (P value= 0.003). Conclusion: finding highly significant differences of serotonin levels in types of leukemia (ALL, AML, CLL, and CML) at p< 0.05.