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Maryam M. Nasser Muthana I. Maleek Zainulabdeen AL-badri

Abstract

Objective: Beta-thalassemia syndrome are a collection of genetic blood disorders characterized by condensed or absent beta globin chain synthesis, causing in reduced Hb in red blood cells (RBC), decreased RBC production and anemia. Thalassemia major refers to a severe phenotype which occur when patients are homozygous or compounds heterozygous for β chain mutation, patients usually present with symptoms within the first two years of life. Aim: The study aimed to evaluate serotonin level and its effect on β-thalassemia patients and investigate the production of the inflammatory cytokine tumor necrosis factor alpha (TNF-α) in serum and their relationship with ferritin serum level in transfusion dependent β-thalassemia patients. Methods: Measurements of serotonin and TNF-α was by using enzyme-linked immunosorbent assay (ELISA). Ferritin was measured automatically by Cobas e 411 device .The study has been carried on patients with β- thalassemia major disease registered at Thalassemia hematology center in Al-Kut women &children Hospital in Wasit province / Iraq. A total 85 samples were included in this study, 55 patients with β- thalassemia major and 30 samples as a control and evaluate result used P≤0.05. Results: Results showed reduced serotonin level in β-TM patients and revealed a significant correlation at (P≤0.02) when compared with control. Serum ferritin level highly increased in blood transfusion dependent β-TM patients and its presented significant correlation (P≤0.001) in patients when compared with control group. Highly TNF-α level increased in β-thalassemia patients and it’s correlated positively in patients when compared with healthy controls. Serotonin, ferritin and TNF-α revealed no significant correlation (P>0.05) with age when compared between the two age groups of β-thalassemia patients less and more than 15 years old.

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Keywords

B-thalassemia patients, serotonin, ferritin, TNF-α

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