Cytotoxicity of Alcoholic Extract of Xanthium Strumarium Against Different Cancer Cell Lines

Abstract

Cancer is a disease that is associated with the abnormal proliferation and growth of living cells. A variety of approaches and methods are employed clinically for the treatment of cancer; however, each of these approaches or methods has some significant limitations especially adverse effects. Xanthium strumarium is a well known herb which has been used since ages as a cure for various ailments like leucoderma biliousness, epilepsy, salivation, fever and poisonous bites of insects. The most important chemical constituents of Xanthium strumarium include phenolic compounds. The study attempted to help in developing a proper treatment for cancer. The study attempted to help in developing a proper treatment for cancer. This study aimed to investigate the possible in vitro cytotoxicity of Xanthium strumarium alcoholic extract on different cancer cell line (Brest cancer, Liver cancer and skin cancer) using MTT reduction assay. The result showed that the MCF-7 and HepG2 were the most sensitive to X. strumarium ethanolic extract and A375 had the lower response. Further studies are needed to uncover the mechanism and chemical constituents of the obtained activity of X. strumarium.