Study of Anitulcer Activity of Leaves Extract of Ficus Racemosa Linn in Various Solvents on Experimental Animals

Abstract

The most prevalent gastrointestinal ailment in the world with high mortality and morbidity is peptic ulcer disease (PUD). Antiulcer medications currently on the market include a number of side effects, including hypersensitivity, arrhythmia, impotence, gynecomastia, haematological abnormalities, and kidney disease. Globally, primary healthcare is largely provided by traditional medicine. To identify the presence of typical phytochemical components, several qualitative and quantitative analyses were performed on the crude extract of Ficus racemosa. The purpose of the current study was to examine various solvents' ability to treat ulcers. Ficus racemosa Linn. leaf extract in albino rats. The ethanol-induced gastric ulcer, free and total acidity, and pylorus-ligated ulcer methods were used to evaluate antiulcer activity. The leaves of Ficus racemosa were successively extracted using the soxhlet extraction method with petroleum ether (60-80 C), chloroform, ethyl acetate, Petroleum ether, ethanol, methanol, and water. Their colour consistency, phytochemical assessment, phytoconstituents like glycosides, saponins, and phytosterols were assessed, as well as the percent yield. Flavonoids, phenols, steroids, and terpenoids all tested positively in early tests on the various extracts. According to fractionation experiments, the methanol fraction had the strongest antiulcer efficacy, while the chloroform fraction was determined to be the least effective. The leaves of Ficus racemosa might be a promising choice for the treatment of PUD in people due to their antiulcer action and safety profile.