Chemerin Gene Polymorphisms and Their Association with Risk of Diabetes Mellitus Type2 in A Sample of Iraqi Patients

Abstract

Type 2 diabetes mellitus was first identified as a component of the metabolic syndrome in 1988.Genetic, environmental, and behavioral risk factors interact to cause it. The most prevalent form of diabetes, Type 2 DM, affects between 90 and 95 percent of diabetics.A number of potential gene polymorphisms that may influence susceptibility to T2DM, obesity, and type-2 diabetes mellitus (T2DM) are associated with dysregulation of adipokines. These candidate genes include adipokines.Chemerin is a novel adipokine that regulates inflammation, adipogenesis, and glucose metabolism by acting as an endocrine signaling molecule. This research included 100 blood samples collected from type 2 diabetes patients divided into normal-weight T2DM patients (n = 50) and obese patients with T2DM (n = 50) and 50 apparently healthy subjects as a control, which was collected from Al-Jadriya International Medical Center during the month of November 2019 until October 2020.The results showed that serum fasting blood sugar were in apparently healthy subjects significantly (p< 0.01) lower than those of normal weight T2DM patients and obese T2DM patients.In addition, serum HbA1c levels were significantly (p 0.01) lower in apparently healthy subjects than in normal weight T2DM patients and obese T2DM patients. DNA samples for the three study groups were genotyped for chemerin gene SNP (rs17173608). Normal weight T2DM patients had a significantly higher percentage of the G allele (p 0.05) than obese T2DM patients and apparently healthy subjects, and normal weight T2DM patients had a significantly higher frequency of the GG genotype (p 0.05) than obese T2DM patients and apparently healthy subjects. In conclusion, a risk factor for type 2 diabetes mellitus in Iraqi patients of normal weight is the GG genotype and G allele of the rs17173608 SNP at the chemerin gene.