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Rawaa Adday Ali Angham Jasim Mohammed Ali Nabil Salim Saaid Tuwaij

Abstract

In the population, the incidence of S. aureus isolates among diabetic foot ulcers (DFUs) has become a major issue. As a result, the goal of this study to investigation and distribution for immunological characterization among S. aureus from diabetic foot ulcer infection. There were 42 (70 %)) men and 18 (30 %)) females among the 60 patients (non-duplicate). The S. aureus isolates were identified using biochemical tests, and the Vitek-2 compact system verified that 37/60 (61.6 %) of the isolates were S. aureus. The immunological study included investigation the level of CD4 in patients human and experimental animals(rabbits) serum. The investigation of CD4 level explained a significantly lower in DM- foot ulcer compared with both the healthy control group and DM non - foot ulcer (P<0.05). The age group > 61 years within the DM-foot ulcer group patients showed significantly decreased in CD4 level compared to both DM-non foot ulcer and controls healthy with a significant difference.P <0.05. As for there is no effects of sex and comorbidity, type DM, and treatment on CD4 level in all study groups. The greatest percentage of infected was Grade2 (43.3%) then Grade3 (23.3%) with significant difference,P <0.05. Also, the study showed that the level of CD4 level in rabbits groups (after inducing the infection by S. aureus that isolate from diabetic foot ulcer patients) significantly decreased compared with both the healthy control rabbits and rabbits groups (before the infection) P <0.05 while we noticed that there was no significant difference between the rabbits groups healthy control and before infected (P>0.05).

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Keywords

DFU, Bacteria, CD4, DM-foot ulcer, Rabbits, DM.

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