Evaluation of Growth Differentiation Factor-15 and Ampk Level in Hypothyroidism with Hyperlipidemia Patients

Abstract

The study was conducted at the Specialized Center for Endocrinology and Diabetes in Al-Sadder Medical City in Najaf Governorate, Iraq throughout the period from first of April to first of September 2021 to determine the relation between physiological, immunological and biochemical marker in hypothyroidism with hyperlipidemia in both sexes. The study was included 90 blood samples, 60 blood sample from male and female affected with hypothyroidism with hyperlipidemia where their age ranged between 20 to 60 years and 30 blood samples as a control group in the same age range. Body mass was measured for both groups.

Blood samples of male and female with hypothyroidism and  hyperlipidemia and control were divided into Three groups depending on patients age, the  first age group (20-34) years (27 samples), the second group (35-49) years (13 samples), the third group (>=50) years (20 samples), and were divided into Three categories depending on BMI the normal weight in patients (7 sample) and control (13 sample), overweight patients (22 sample) control (11 sample) and obesity patients (31 sample) control (6 sample) respectively.

The study compared the age, gender, BMI, lipid profile, thyroid hormone and AMPK, and GDF-15 biomarkers between patients with hypothyroidism and hyperlipidemia and control group. The results revealed that there were no significant differences in age (P<0.05) between patients and controls, while there were significant differences (P<0.05) in gender, BMI, lipid profile, thyroid hormone and AMPK GDF-15 biomarkers between patients and controls.

The study compare the level of AMPK and GDF-15 biomarkers between male and female patients, the results showed that AMPK  was not-significant (P<0.05) between male and female patients, and result show significant differences in GDF-15 (P<0.05) between male and female patients, also the results showed that AMPK and GDF-15 non-significant (P>0.05) between age categories in patients, and results showed significant  differences (P<0.05) between BMI categories and AMPK and GDF-15 in patients and control.

The study showed there was positive correlation of levels AMPK and GDF-15 biomarkers with age, lipid profile and thyroid hormone in patients, the results showed that negative correlation of levels AMPK and GDF-15 and age, Total Ch., TG, LDL, VLDL and TSH, but there was positive correlation with HDL, T3 and T4 except GDF-15 there was no significant correlation with T3.

In conclusions AMPK and GDF-15 levels biomarkers are decreased in patients with hypothyroidism with hyperlipidemia.