Determination of Some Biomarkers as Pathological Etiology and Risk Factors in Patients with Type Two Diabetes Mellites

Abstract

Background: Type 2 diabetes mellitus (T2DM) is the most severe form of diabetes, accounting for 90-95 percent of cases. It is characterized by a combination of insulin resistance and insulin cell secretion pancreatic dysfunction, resulting in a metabolic abnormality. Aims: assess the diagnostic value of FBS, Hba1c, Lipid profile, insulin, Homo insulin resistance, Leptin, Plasminogen activator inhibitors 1, TNF alpha, lipase lipoprotein, Apo B and Apo A1 biomarkers in patients with type two diabetes Mellitus.              Materials and methods: A case control study a total of 80 patient and 50 control groups, used Cobas E311 device for measure glucose and lipid profile, HbA1c used D-10 hemoglobin Hba1c device whereas other parameters used ELISA methods were used to analyses 130 samples Results: increased level of Insulin, Tg, HOMA IR, Leptin Apo A1 l and Apo B lipoprotein, whereas decrease level of PAI-1, HDL, TNF and Lipoprotein lipase. Conclusion: FBG, HbA1c, Insulin and HOMA-IR were Highly sensitivity and specificity in the diagnosis accuracy of type 2 diabetes.