Determination the Relationships between Body Mass Index and Incidence of Rheumatoid Arthritis

Abstract

Rheumatoid arthritis (RA) a class of systemic auto immune disturbances and manifest its Self with progression inflammation of several Joint in the body. The present results was co conducted to evaluate some hematological parameters and some biomarkers in Patients affected with RA of both Sexes (men and women (. The individuals who had involved in the present Study were 80 subject of Patients and healthy individual and they classified according to gender into two Subclasses, the first one involved 40 males that divided into 20 Males Patients with RA and 20 Males healthy control. The second class had also 40 females of them 20 females affected with RA and 20 healthy females as a control group. All ages of Subject were ranged between 40-79 years old and then according to their age’s war classified into four age groups (40-49, 50-59 60-69, 70-79 Years old (. The demographical data that obtained from the Present study indicated that the Percentage ratio of women with RA was 60% higher than Men with RA who had recorded 40% The distribution of Patients according to their age groups the Percentage ratios were the following to 49 first group 30%, Second group 30% Third group 25% fourth group 15% respectively). In addition the Percentage ratios of RA Patients according to body Mass index (BMI) it was found Patients with that had BMI equal to 25 -33 kg/m² comprised 70% higher than those patients who had BMI ranged between 19-23 kg/m² (30%). The changes of hematological Parameters had been exhibited a significant increase (P<0.001) in the Level of white blood cells (WBCs), in all RA patients groups when compared with those healthy one. The correlation Coefficients occurring among Studied hematological Parameters recorded the following data, it was found that then is a significant positive correlation (r=0.43, Sig=0.005) occurring between ESR and WBCs The observations recorded around studied biomarkers including rheumatoid factor (RF), fibrinogen, tumor necrosis factor alpha (TNF), and granulocytes-monocytes Colony stimulating factor (GM-CSF) were showed a significant elevation (P<0.05) in all levels, of these biomarker of all patients groups compared to healthy subjects. These studied biomarkers appear closely associated with BMI therefore their levels were significantly high P<0.05 in RA Patients with BMI 25-33 kg/m² Comparing to those patient had BMI ranged between 19 - 23 kg/m². The Correlation coefficients of biomarkers with other Studied Parameters as follow, there is a significant Positive correlation between ESR and TNF-α , ESR and GM-CSF, ESR and RF, GM-CSF and Platelets, Gm-CSf and WBS, Gm-CSF and granulocytes, GM-CSF and fibrinogen, GM-CSF and RF, Gm-CSF and CRP, TNF-α and GM-CSR , TNF-α and platelets , TNF-α and WBC, TNF and granulocytes, TNF-α and RF , TNF-α and CRP ,WBC, and CRP, Rf and platelets, RF and WRCs , of all Patients with RA.