Synthesis, Characterization of ‎Schiff Base Derived from ‎2-‎Aminobenzothiazole and Evaluation of its Anti-Bacterial Efficacy

Abstract

This study includes the preparation of derivatives of Schiff bases (R6-R10) from isotonic reactance of substituents of para-benzaldehyde (4-bromobenzaldehyde, 4-chlorobenzaldehyde, 4-nitrobenzaldehyde, 4-methoxy benzaldehyde, 4-dimethylaminobenzaldehyde) with 2-aminobenzothiazole, using ethanol as a solvent. Physical properties such as melting point, colour, and molecular weight and spectroscopic measurements such as the infrared spectrum, [1H-NMR], [13C-NMR] spectrum were used to confirm the accuracy of the prepared compounds' compositions. The biological activity of various produced compounds was investigated in two species of pathogenic bacteria, one of which is Gram-positive, Staphylococcus aureus, and the other, Gram-negative, Pseudomonas aeruginosa. Chemical solutions for the compounds (R6, R8, and R9) with concentrations (0, 01, 0.001, and 0.0001) mg /ml were created using a solvent DMSO and Multer Hinton Agar growth medium. The antibiotic Ciprofloxacin was utilized as a control sample for the diffusion sensitivity test of the bacterial isolates used in the investigation.