Effect of metformin treatment on hematological parameters, HOMA-IR in patients with type 2 diabetes mellitus

Abstract

Aim: To assess BMI and the serum of HbA1c, Creatinine, HOMA-IR and QUICKI and hematological parameters in patients with T2DM were taking metformin in Iraq. Methodology: this is a cross-section study using case series of 80 patients with T2DM coming to the Baghdad Teaching Hospital Medical city, between December 2021 and April 2022. The blood sample was drawn to measure HbA1c, Creatinine, HOMA-IR, QUICKI and hematological parameters. The statistical analysis was conducted using the SPSS statistical package to analyze date. Results: According to the findings, there was a significant difference between the control group and T2DM patients undergoing metformin therapy in terms of blood levels of Creatinine, HOMA-IR and QUICKI and RBC except hematological parameters were non-significant. Conclusion: Body Mass Index, chemical parameters (HbA1c, Creatinine, HOMA-IR, QUICKI) and RBC were affecte to patients receiving metformin treatment for type 2 diabetes but regardinghematological parameters were non-affected compared with control group