Synthesis and Characterization of some Metal Complexes with new Ligands Derived from Amino Acid and study Biological Activity

Abstract

A novel 3-(3-(thiophene-2-carbonyl)thiorido)pyrazine-2-carboxylic acid (TPA) of 3-aminopyrazine-2-carboxylate and 2-thiophene carbonyl chloride, used for the synthesis of a series of new cobalt(II) mineral complexes Nickel (II), copper (II), cadmium (II), mercury (II). The mineral complexes were characterized by elemental analyzes (C.H.N.S), molar conductivity, and spectroscopic techniques: FT-IR, 1H- NMR, 13C- NMR, UV-Vis, Mass spectra, and magnetic properties. The results confirmed that the ligand (TPA) behaves as a Bidentate and coordinates with the metal ion via the nitrogen atom of the amine group and an oxygen atom of the carboxyl group. The antimicrobial properties of all newly synthesized compounds were also demonstrated against the bacterial pathogenic organisms Staphylococcus aurous (G+) and Escherichia coli (G-) by the agar-well diffusion technique. These complexes are more effective against bacteria compared to the penicillin antibiotic. Cytotoxicity tests for the ligand and the mercury complex have also been performed, and in vitro studies on gastric cancer cell lines as well as normal cells (HUVEC) have shown that cancer cells absorb healthy compounds and increase their activity against cancer cells.

The aim of this study describes the synthesis and characterization of the new ligand (TPA) derived from pyrazine and its metal complexes with knowing their effect on selected bacteria. And anti-cancer- activities